immunology

Wistar scientists unveil a novel ADAR1-SIRT1-p16INK4a axis in regulating cellular aging

Aging and age-related disorders present a complex challenge to the biomedical research community. To better understand how aging is regulated, it is vital to promote healthy aging and treat age-related conditions. In a research paper published today in Nature cell biologyRugang Zhang, Ph.D., deputy director of the Ellen and Ronald Caplan Cancer Center, Christopher M. …

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Researchers create a comprehensive map of how complex networks of genes work together

Using new technologies to study thousands of genes simultaneously in immune cells, researchers from Gladstone Institutes, UC San Francisco (UCSF) and Stanford School of Medicine have created the most detailed map yet of how complex networks of genes work together. The new insights into how these genes relate to each other shed light on the …

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A boosted gene promoter stops heat from undermining plant defenses

Overview Plants’ immune defenses falter during heat waves, making them more vulnerable to insects and pathogens under climate change. HHMI scientists have now discovered why high temperatures disable an important defense system and have devised a strategy that boosts plant immunity. Plants’ immune systems depend on the hormone salicylic acid, which helps refine their defenses …

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