neurons

Gene therapy approach delays disease onset in humanized mouse models of familial ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord responsible for voluntary movements and muscle control. In a new study, published July 11, 2022 in the journal Theranostics, researchers from the University of California San Diego School of Medicine report that a …

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DZNE and Intravacc Receive €2.5M EU Funding to Develop Prototype ALS Vaccine

DZNE and Intravacc BV, a leading global contract development and manufacturing organization (CDMO) of preventive and therapeutic vaccines, have received €2.5 million funding from the European Union (EIC Transition Grant) to further develop a prototype ALS vaccine , including process development, upscaling and toxicological research. The project aims to develop the vaccine candidate identified at …

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Gene defect underlying Krabbe disease directly causes neuron degeneration, study finds

The gene defect underlying Krabbe disease directly causes neuron degeneration, independent of its effects on other cell types, according to a new study published July 5.e in the open access journal PLOS Biology by Daesung Shin of the University at Buffalo, USA and colleagues. The discovery represents a new mechanism of action for the mutant …

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A convergent mechanism for two highest-ranking risk genes may be responsible for ASD/ID

Scientists at the University at Buffalo have discovered a convergent mechanism that may be responsible for how two highly regarded genetic risk factors for autism spectrum disorder/intellectual disability (ASD/ID) lead to these neurodevelopmental disorders. While ASD is different from ID, a significant part is -; about 31% -; of people with ASD also show an …

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Roundworms shed light on vision loss in rare human genetic disorder

In this interview, News-Medical speaks with Xinxing Zhang, a postdoctoral researcher at the University of Michigan, about his research on vision loss in Bardet-Biedl syndrome. Can you introduce yourself, tell us about your scientific background and what inspired your latest research? I used a model organism called C. elegans in my Ph.D. and postdoctoral studies …

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