Research

NUS researchers discover a new way to interpret unresolved Mendelian diseases

The development of an embryo is a well-orchestrated series of processes that ensure the correct formation and positioning of vital organs of the growing organism. At the molecular level, these processes are precisely controlled by switching certain factors such as genes or proteins on or off. Any errors in these processes can lead to physical …

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Study shows genotype leads to discontinued, reduced medication | VUMC reporter

by Jill Clendening Patients whose race is registered as black on their electronic health record (EHR) are more likely to have azathioprine, an immunosuppressant, discontinued or dose reduced because their lab results show low white blood cell counts. This lab finding wasn’t a factor of race, but was instead linked to a genetic variant found …

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Researchers discover a molecular switch that promotes the metastasis of pancreatic cancer

More than 62,000 people in the United States will be diagnosed with pancreatic cancer by the end of this year, with the vast majority having a deadly and aggressive subtype known as pancreatic ductal adenocarcinoma (PDA). PDA affects more than 90% of pancreatic cancer patients and has a mean 5-year survival rate of less than …

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Australian study aims to unravel the mystery of extreme menstrual pain in young people

About half of the world’s population suffers from it every month, but even today, the mystery still surrounds menstrual cramps. Most important points: More than 80 percent of teenage girls have experienced menstrual pain Researchers try to understand why it’s more serious for some They are currently recruiting participants in the Northern Territory How can …

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Molecular tumor profiling in pediatric cancer patients has a significant impact on clinical care

Results from a molecular tumor profiling study in young patients revealed a high degree of genetic alterations potentially impacting clinical care, including clarifying diagnoses and treatment with matched, accurate cancer drugs. Report in naturopathyResearchers at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center said that molecular profiling of solid tumors found clinically significant genetic variations …

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Vials of vaccines stack up along a conveyor belt

COVID vaccines saved 20 million lives in first year, but we could have done better, scientists say

New research shows nearly 20 million lives were saved by COVID-19 vaccines during the first year of use, but even more deaths could have been prevented if global targets had been met. Most important points: The researchers used data from 185 countries collected between December 8, 2020 and December 8, 2021 The vaccines prevented 4.2 …

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Arora receives $3.7 million grant to assess “genome-first” approach to improving cardiometabolic health through heart hormones – News

The grant will be used to fund a first-of-its-kind clinical trial that will recruit healthy individuals through a “genome-first” approach and perform in-depth metabolic phenotyping to understand the underlying mechanisms responsible for regulation. of the metabolism of the human body by means of natriuretic peptide hormones. The grant will be used to fund a first-of-its-kind …

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TB-causing bacteria can evolve rapidly in response to new environments, study says

Researchers have identified how the bacteria that causes tuberculosis (TB) can evolve rapidly in response to new environments, according to a study published today in eLife. As with other types of bacteria, Mycobacterium tuberculosis †M. tuberculosis) is able to form complex structures called biofilms, which allow bacterial cells to resist stressors such as antibiotics and …

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New molecular information could help develop more effective treatments for melanoma

A new study reveals important molecular information that could help scientists develop more effective treatment and prevention strategies for a difficult-to-treat form of melanoma skin cancer. In this new report, researchers from Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) identify and …

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Researchers identify orally effective antiviral drug against respiratory syncytial virus

An oral antiviral drug has been identified that targets a key component of the respiratory syncytial virus (RSV) polymerase and inhibits the synthesis of viral genetic material. Antiviral Research at Georgia State University. The findings, published in the journal scientific progress, AVG-388 as the lead drug candidate, which effectively blocks the activity of the viral …

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